Waterloo Regional Police are investigating a car crash in Cambridge that sent four people to hospital.

Police say a pick-up truck collided with a Honda Civic at the intersection of Franklin Boulevard and Main St. around 5:30 p.m. Friday.

One person had life-threatening injuries and was airlifted to Hamilton General Hospital. Three others were taken to area hospitals with varying injuries ranging from serious to life-threatening.

The driver of the pick-up truck walked away unharmed.

The intersection was shut down for more than four hours as police investigated the crash.