The eastbound lanes of Highway 7 in New Hamburg were shut down for a short time Sunday after a crash at the Peel Street/Haysville Road intersection.
Police say a vehicle tried to make a left turn onto Peel Street.
Another vehicle, travelling in the opposite direction, slammed into its side.
Five people were taken to hospital with minor injuries.
Highway 7 at Peel Street/Haysville Road has now reopened.
Police say charges are pending.