Cash and drugs were seized from a home in the Preston area of Cambridge, Waterloo Regional Police say.
A search warrant was executed at 3 a.m. Thursday at the home, located on Church Street South.
Inside, police allegedly found $4,800 in cash as well as cocaine and marijuana with a total estimated street value of $4,200.
Three men and two women are jointly charge with possession for the purpose of trafficking.
Some members of the group also face additional charges.