Middlesex County OPP closed a stretch of Highway 4 north of London Saturday afternoon while they investigate a fatal crash.
They say a black minivan struck a white cube van on Richmond Street (Highway 4) near Eight Mile Road just before noon.
The cube van was stopped at the time, preparing to turn into a private driveway.
The driver of the black minivan, a 54-year-old man, needed to be extricated from his vehicle.
He was taken to a nearby hospital with life-threatening injuries.
He died a short time later.
His name has not yet been released.
The two people inside the cube van were not injured.