An 18-year-old woman is dead following a two-vehicle crash south of Ohsweken.

Haldimand County OPP say they along with the Six Nations fire, police and paramedic departments were called to the corner of Mississauga and Tuscarora roads around 5:30 p.m. Monday.

The 18-year-old, a Six Nations resident, was pronounced dead at the scene.

Three people in the other vehicle were seriously hurt, including a 49-year-old Six Nations woman who was airlifted to Hamilton General Hospital with life-threatening injuries.

Police say they continue to investigate the cause of the crash.